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desvenlafaxine will increase the amount or impact of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Caution/Observe. Desvenlafaxine inhibits CYP2D6; with bigger desvenlafaxine doses (ie, four hundred mg) lessen the CYP2D6 substrate dose by around 50%; no dosage adjustment required with desvenlafaxine doses seven consecutive times prom

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